Dysfunctional epigenetic aging of the normal colon and colorectal cancer risk
Ontology highlight
ABSTRACT: Genome wide DNA methylation profiling of normal colon samples. The Illumina Infinium HumanMethylation450 and EPIC Beadchip arrays were used to obtain DNA methylation profiles across approximately 450,000 and 850,000 CpGs. Samples were from nomal colons of 334 subjects with low, medium or high CRC risk according to their personal adenoma or cancer history.
Project description:Genome-wide DNA methylation profiling of 10 pediatric bithalamic diffuse gliomas. The Illumina Infiunium 450k Human DNA Methylation Beadchip (n=4) or the Infinium EPIC 850k Human DNA Methylation Beadchip (n=6) was used to obtain DNA methylation profiles across approximately 450,000 or 850,000 CpG sites of genomic DNA extracted from formalin-fixed, paraffin-embedded tumor tissue of 10 pediatric bithalamic diffuse gliomas.
Project description:Genome wide DNA methylation profiling of paired parental and therapy resistant cancer cell lines. Parental cell lines are mostly established cell lines. Resistant cell lines were obtained through long term exposure of the parental cells to gradually increasing doses of cancer therapies. The Illumina Infinium 450k and EPIC Human DNA methylation Beadchips were used to obtain DNA methylation profiles across approximately 450,000 or 850,000 CpGs from the cells. Samples include 7 parental and 10 derived resistant cell lines.
Project description:Genome wide DNA methylation profiling of paired parental and therapy resistant cancer cell lines. Parental cell lines are mostly established cell lines. Resistant cell lines were obtained through long term exposure of the parental cells to gradually increasing doses of cancer therapies. Followig the published TAB-sequencing protocol, the Illumina Infinium 450K or EPIC Human DNA methylation Beadchips were used to obtain DNA hydroxymethylation profiles across approximately 450,000 or 850,000 CpGs from the cells. Samples include 5 parental and 6 derived resistant cell lines.
Project description:The Illumina Infinium Epic Human DNA methylation Beadchip was used to obtain DNA methylation profiles across more than 850,000 CpGs.
Project description:Genome-wide DNA methylation profiling of melanoma samples. The Illumina Infinium Human DNA methylation EPIC Beadchip Kit was used to obtain DNA methylation profiles across approximately 850,000 CpGs.
Project description:Genome-wide DNA methylation profiling was conducted using DNA isolated from MNKPL. The Illumina EPIC methylation Beadchip array which covers more than 850,000 CpG loci was used. Samples include 7 cases.
Project description:The Illumina Infinium EPIC/850k Human DNA methylation Beadchip was used to obtain DNA methylation profiles across approximately 850,000 CpGs in a total of 168 samples, 24 from females and 144 from males
Project description:DNA methylation markers in thyroid tumor We used Illumina HumanMethylation EPIC bead array containing over the 850,000 CpG sites in 34 thyroid normal and tumor samples to identify thyroid subtype-specfic DNA methylation markers.
Project description:The level of dNA methylation in BRE80-BRE80-T5 and T47D cells expressing active and inctive DNMT3A was quantified using EPIC array across more than 850,000 CpGs
Project description:Genome wide DNA methylation profiling of pediatric acute myeloid leukemia obtained from bone marrow. The Illumina EPIC methylation beadchip array was used to obtain DNA methylation profiles across approximately 850,000 CpG dinucleotide methylation loci in DNA isolated from leukemia. Samples include 64 patients.