Methylation profiling

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DNA hydroxymethylation profiling of paired parental and therapy resistant cancer cell lines

ABSTRACT: Genome wide DNA methylation profiling of paired parental and therapy resistant cancer cell lines. Parental cell lines are mostly established cell lines. Resistant cell lines were obtained through long term exposure of the parental cells to gradually increasing doses of cancer therapies. Followig the published TAB-sequencing protocol, the Illumina Infinium 450K or EPIC Human DNA methylation Beadchips were used to obtain DNA hydroxymethylation profiles across approximately 450,000 or 850,000 CpGs from the cells. Samples include 5 parental and 6 derived resistant cell lines.

ORGANISM(S): Homo sapiens

PROVIDER: GSE128685 | GEO | 2020/02/20

REPOSITORIES: GEO

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