Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptomic analysis of class I odorant receptor enhancer deletion [eB]

ABSTRACT: We used RNAseq based transcriptome analysis to compare gene expression changes in the olfactory mucosa resulting from CRISPR-based deletion of a putative enhancer in the class I odorant receptor gene cluster.

ORGANISM(S): Mus musculus

PROVIDER: GSE133818 | GEO | 2019/07/04

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Transcriptomic analysis of class I odorant receptor enhancer deletion [eA]

Project description:We used RNAseq based transcriptome analysis to compare gene expression changes in the olfactory mucosa resulting from CRISPR-based deletion of a putative enhancer in the class I odorant receptor gene cluster.

2019-07-04 | GSE133817 | GEO

Transcriptomic analysis of class I odorant receptor enhancer deletion [LD]

2019-07-04 | GSE133820 | GEO

Transcriptomic analysis of class I odorant receptor enhancer deletion [eC]

2019-07-04 | GSE133819 | GEO

Transcriptomic analysis of class I odorant receptor enhancer deletion [eB]

Project description:Transcriptomic analysis of class I odorant receptor enhancer deletion [eB]

| PRJNA552596 | ENA

Transcriptomic analysis of class I odorant receptor enhancer deletion

Project description:Transcriptomic analysis of class I odorant receptor enhancer deletion

| PRJNA552594 | ENA

Transcriptomic analysis of class I odorant receptor enhancer deletion [LD]

Project description:Transcriptomic analysis of class I odorant receptor enhancer deletion [LD]

| PRJNA552595 | ENA

Transcriptomic analysis of class I odorant receptor enhancer deletion [eA]

Project description:Transcriptomic analysis of class I odorant receptor enhancer deletion [eA]

| PRJNA552600 | ENA

Transcriptomic analysis of class I odorant receptor enhancer deletion [eC]

Project description:Transcriptomic analysis of class I odorant receptor enhancer deletion [eC]

| PRJNA552597 | ENA

A Long-Range cis-Regulatory Element for Class I Odorant Receptor Genes

Project description:Individual olfactory sensory neurons express a single odorant receptor (OR) gene from either class I genes residing in a single cluster on a single chromosome or class II genes spread over multiple clusters on multiple chromosomes. Here, we identify an enhancer element for mouse class I genes, the J element, that regulates class I gene expression of a much larger number of genes and over a much greater genomic distance than known class II gene enhancers. Our data reveal an extraordinary long-range cis-regulatory element that governs the singular class I gene expression and has been phylogenetically preserved to retain a single cluster organization of class I genes in mammals.

2017-07-23 | GSE90700 | GEO

Silencing of odorant receptor gene expression by G protein M-NM-2M-NM-3 signaling ensures the expression of one odorant receptor per olfactory sensory neuron

Project description:Olfactory sensory neurons express just one out of a possible ~1000 odorant receptor genes, reflecting an exquisite mode of gene regulation. In one model, once an odorant receptor is chosen for expression, other receptor genes are suppressed by a negative feedback mechanism, ensuring a stable functional identity of the sensory neuron for the lifetime of the cell. The signal transduction mechanism subserving odorant receptor gene silencing remains obscure, however. Here we demonstrate in the zebrafish that odorant receptor gene silencing is dependent on receptor activity. Moreover, we show that signaling through G protein M-NM-2M-NM-3 subunits is both necessary and sufficient to suppress the expression of odorant receptor genes, and likely acts through histone methylation to maintain the silenced odorant receptor genes in transcriptionally inactive heterochromatin. These results provide new insights linking receptor activity with the epigenetic mechanisms responsible for ensuring the expression of one odorant receptor per olfactory sensory neuron. Total 6 samples were analyzed-3 controls & 3 samples

2013-12-16 | E-GEOD-53334 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data