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Transcriptomic analysis of class I odorant receptor enhancer deletion

ABSTRACT: Transcriptomic analysis of class I odorant receptor enhancer deletion

PROVIDER: PRJNA552594 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR9642680_1.fastq.gz	Fastqsanger.gz
	SRR9642680_2.fastq.gz	Fastqsanger.gz
	SRR9642690_1.fastq.gz	Fastqsanger.gz
	SRR9642690_2.fastq.gz	Fastqsanger.gz
	SRR9642700_1.fastq.gz	Fastqsanger.gz

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Project description:Individual olfactory sensory neurons express a single odorant receptor (OR) gene from either class I genes residing in a single cluster on a single chromosome or class II genes spread over multiple clusters on multiple chromosomes. Here, we identify an enhancer element for mouse class I genes, the J element, that regulates class I gene expression of a much larger number of genes and over a much greater genomic distance than known class II gene enhancers. Our data reveal an extraordinary long-range cis-regulatory element that governs the singular class I gene expression and has been phylogenetically preserved to retain a single cluster organization of class I genes in mammals.

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Silencing of odorant receptor gene expression by G protein M-NM-2M-NM-3 signaling ensures the expression of one odorant receptor per olfactory sensory neuron

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