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CpG dinucleotides introduced into gag can inhibit HIV-1 gene expression by modulating pre-mRNA splicing

ABSTRACT: Progressively longer regions of the gag gene sequence in HIV-1 were codon-optimized, which introduced 11, 18 or 26 CpGs (CM22-165: codon-optimized gag from nucleotide 22 to 165, adding 11 CpGs; CM22-261: 18 CpGs; CM22-378: 26 CpGs).

ORGANISM(S): Homo sapiens

PROVIDER: GSE134159 | GEO | 2019/11/07

REPOSITORIES: GEO

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