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PGR-B expression in the ovary drives ovarian neoplasia and a tumorigenic transcriptome.

ABSTRACT: Constitutive PGR-B expression in PGR positive cells in the mouse drives ovarian neoplasia. To compare the differences between the PGR-B expressing ovarian neoplasia tissue and age-matched wildtype ovaries, microarray analysis was performed. It was concluded that PGR-B expression promoted a tumorigenic signature distinctly different from wildtype ovarian tissue.

ORGANISM(S): Mus musculus

PROVIDER: GSE137432 | GEO | 2020/09/10

REPOSITORIES: GEO

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PGR-B is responsible for a proliferative gene signature in ovarian neoplasia in PGR-B expressing mice.

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