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PGR-B is responsible for a proliferative gene signature in ovarian neoplasia in PGR-B expressing mice.

ABSTRACT: PGR-B is responsible for a proliferative gene signature in ovarian neoplasia in PGR-B expressing mice.

PROVIDER: PRJNA565732 | ENA |

REPOSITORIES: ENA

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PGR-B is responsible for a proliferative gene signature in ovarian neoplasia in PGR-B expressing mice.

Project description:Constitutive PGR-B expression in PGR positive cells in the mouse drives ovarian neoplasia. Chronic treatment with RU486 reduced tumor growth in these PGR-B expressing mice. To further identify how PGR-B functions to promote sustained tumor growth, PGRcre/+ PGR-BLsL/+ mice with ovarian tumors were administered a chronic-release pellet of RU486 or placebo for 24 hours. Tissue was harvested and RNA was isolated. After comparative analyses, it was concluded that PGR-B promotes cell cycle regulatory genes and oncogenic signaling pathways.

2020-09-10 | GSE137499 | GEO

PGR-B expression in the ovary drives ovarian neoplasia and a tumorigenic transcriptome.

Project description:Constitutive PGR-B expression in PGR positive cells in the mouse drives ovarian neoplasia. To compare the differences between the PGR-B expressing ovarian neoplasia tissue and age-matched wildtype ovaries, microarray analysis was performed. It was concluded that PGR-B expression promoted a tumorigenic signature distinctly different from wildtype ovarian tissue.

2020-09-10 | GSE137432 | GEO

PGR-B directly binds to promoters of genes important for cell cycle, proliferation, and tumorigenesis within ovarian neoplasia from PGRcre/+mPGRBLsL/+ mice

Project description:Long-term expression of PGR-B in the PGRcre/+mPGRBLsL/+ mice results in ovarian neoplasia as early as 23 weeks of age. Microarray analyses in the ovarian tumors exhibit strong molecular signatures of proliferation and tumorigenesis. In order to identify if PGR-B was directly promoting this tumorigenic agenda, ChIP-Seq was performed on ovarian neoplasia from PGRcre/+mPGRBLsL/+ mice at greater than 7.5 months of age. These data suggest PGR-B directly promotes cell cycle related genes, driving the uncontrolled growth in the ovarian tissue.

2020-09-10 | GSE137548 | GEO

Gene expression analysis of granulosa cells from animals that are wildtype or knockout for total PGR, PGR-A or PGR-B (RNA-seq)

Project description:Progesterone receptor (PGR) is essential for various functions in the female reproductive tract, especially ovulation in the ovary. PGR consists of two main isoforms, PGR-A and PGR-B, that possess different expression patterns and are responsible for various unique roles in different tissue contexts. While both are present in the reproductive tract, PGR-A is the only one known to be essential for ovulation while PGR-B plays a lesser role in the reproductive tract. However, the specific roles of PGR isoforms on gene expression in peri-ovulatory granulosa cells have not been previously investigated in detail. In this study, we identified the unique role of PGR-A and PGR-B in peri-ovulatory granulosa cells through RNA-seq of knockout mouse models for total PGR (PGR KO) or specific isoforms (PGR-A KO and PGR-B KO)

2022-05-18 | GSE168213 | GEO

Genome-wide binding sites of Progesterone receptor (PGR) isoforms PGR-A and PGR-B during differentiation of human endometrial stromal cells

Project description:We report the genome-wide binding sites of PGR-A and PGR-B at 2h of in vitro differentiation of human endometrial stromal cells that express either PGR-A or PGR-B. Progesterone, acting through the progesterone receptors (PGRs), is one of the most critical regulators of endometrial differentiation, known as decidualization, which is a key step toward the establishment of pregnancy. Yet a long-standing unresolved issue in uterine biology is the precise roles played by the major PGR isoforms, PGR-A and PGR-B, during decidualization in the human. Our approach, expressing PGR-A and PGR-B individually after silencing endogenous PGRs in human endometrial stromal cells (HESC), enabled the analysis of the roles of these isoforms separately as well as jointly by ChIP-seq and gene-expression analysis. In order to study the cistromes of PGR-A and PGR-B at 2h of in vitro differentiation of human endometrial stromal cells, we generated primary cultures of human endometrial stromal cells expressing flag tagged PGR-A and PGR-B individually after silencing endogenous PGRs. Input DNA was used as the reference sample.

2015-04-27 | E-GEOD-62475 | biostudies-arrayexpress

PGR-B expression in the ovary drives ovarian neoplasia and a tumorigenic transcriptome.

Project description:PGR-B expression in the ovary drives ovarian neoplasia and a tumorigenic transcriptome.

| PRJNA565428 | ENA

Endometrial transcriptome and PGR cistrome in cycling fertile women [ChIP-seq]

Project description:We report the transcriptomic profile and PGR cistromic profile for endometrial biopsies obtained from fertile women during the proliferative and mid-secretory phase of the menstrual cycle

2019-11-27 | GSE132712 | GEO

Endometrial transcriptome and PGR cistrome in cycling fertile women [RNA-seq]

2019-11-27 | GSE132711 | GEO

Genome-wide binding sites of Progesterone receptor (PGR) isoforms PGR-A and PGR-B during differentiation of human endometrial stromal cells

2015-04-27 | GSE62475 | GEO

RNA-Seq of CTRL and PGR overexpressing MCF7 intraductal xenografts

Project description:Using a large variety of methods we demostrate that PGR can be a driver of tumor proliferation even in absence of extensive E2. In this specific experiment we overexpress PGR in MCF7 cells intraductally xenografted into the ductal tree of a mouse mammary gland, which provides post-menopausal levels of E2. Despite these conditions the cells thrive and with the PGR overexpression the growth rate is double the control cells. PGR overexpressing cells exhibit consistently more invasive and metastatic properties.

2022-04-05 | GSE192808 | GEO

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