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PGR-B is responsible for a proliferative gene signature in ovarian neoplasia in PGR-B expressing mice.

ABSTRACT: Constitutive PGR-B expression in PGR positive cells in the mouse drives ovarian neoplasia. Chronic treatment with RU486 reduced tumor growth in these PGR-B expressing mice. To further identify how PGR-B functions to promote sustained tumor growth, PGRcre/+ PGR-BLsL/+ mice with ovarian tumors were administered a chronic-release pellet of RU486 or placebo for 24 hours. Tissue was harvested and RNA was isolated. After comparative analyses, it was concluded that PGR-B promotes cell cycle regulatory genes and oncogenic signaling pathways.

ORGANISM(S): Mus musculus

PROVIDER: GSE137499 | GEO | 2020/09/10

REPOSITORIES: GEO

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