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Analyzing the transcriptomic response of MCF7 breast cancer cells to NR1H4 agonist GW4064

ABSTRACT: Computational analysis identified NR1H4 as an active nuclear receptor in a xenograft model of breast cancer. Since there is evidence that NR1H4 agonist, GW4064, reduces MCF7 cell proliferation, here, we wanted understand the transcriptional changes induced by activating this nuclear receptor. We measured changes in gene expression due to GW4064-treatment and applied gene set enrichment analysis to further understand the perturbed molecular pathways.

ORGANISM(S): Homo sapiens

PROVIDER: GSE138138 | GEO | 2019/10/01

REPOSITORIES: GEO

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Analyzing the transcriptomic response of MCF7 breast cancer cells to NR1H4 agonist GW4064

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