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Genome-wide mapping of 5-hmC in epithelial samples from IMQ-treated skin versus control skin in mice.

ABSTRACT: Analysis of the tag densities showed lower 5-hmC levels in both CpG islands and genebodies in Imiquimod (IMQ)-treated epidermal samples. We looked further into loci-specific changes of 5-hmC and found a total of 364 differentially hydroxymethylated regions. Within these regions, 321 genes showed significantly lower 5-hmC levels and 67 genes had significantly higher 5-hmC levels in the IMQ-treated epidermis compared to control.

ORGANISM(S): Mus musculus

PROVIDER: GSE138921 | GEO | 2019/12/15

REPOSITORIES: GEO

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