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Genome-wide mapping of 5-hmC in epithelial samples from IMQ-treated skin versus control skin in mice.

ABSTRACT: Genome-wide mapping of 5-hmC in epithelial samples from IMQ-treated skin versus control skin in mice.

PROVIDER: PRJNA577733 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR10288455.fastq.gz	Fastqsanger.gz
	SRR10288456.fastq.gz	Fastqsanger.gz

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Genome-wide mapping of 5-hmC in epithelial samples from IMQ-treated skin versus control skin in mice.

Project description:Analysis of the tag densities showed lower 5-hmC levels in both CpG islands and genebodies in Imiquimod (IMQ)-treated epidermal samples. We looked further into loci-specific changes of 5-hmC and found a total of 364 differentially hydroxymethylated regions. Within these regions, 321 genes showed significantly lower 5-hmC levels and 67 genes had significantly higher 5-hmC levels in the IMQ-treated epidermis compared to control.

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effect of bergapten gel on IMQ mice back skin

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RNA-seq analysis of IMQ-treated wt and Trex2-/- skin

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Expression data from IMQ-induced psoriasis-like skin inflammation in miR-146a-/- and C57BL6J mice

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Project description:RNA-seq of skin of vehicle-treated, IMQ-treated, IMQ+rYopM-treated and IMQ+rYopM_LRR1-3 treated mice.

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Microarray expression data from P50 mouse full thickness back skin of C57BL/6 mice - various durations of IMQ treatment and timepoints.

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