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RNA-seq analysis of WT and NCOR1f/f,Cd4Cre naive CD4+ T cells

ABSTRACT: The differentiation of naïve CD4+ T cells into T helper (Th) subsets is key for a functional immune response and has to be tightly controlled by transcriptional and epigenetic processes. However, the function of cofactors that connect gene-specific transcription factors with repressive chromatin-modifying enzymes in Th cells is yet unknown. Here we determined transcriptional changes in naive CD4+ T cells upon deletion of the cofactor NCOR1.

ORGANISM(S): Mus musculus

PROVIDER: GSE138931 | GEO | 2020/04/03

REPOSITORIES: GEO

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