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Gene expression data from LRRK2-WT and LRRK2-G2019S astrocytes

ABSTRACT: LRRK2-G2019S (LRRK2-GS), a pathogenic mutation in the PD-associated gene LRRK2, promote ER stress-induced cell death by reducing transcriptional activity of X-box-binding protein 1 (XBP1), a key transcription factor of the UPR. We used microarrays to detail the programme of gene expression and identified distinct classes of up-regulated or down-regulated genes during ER stress.

ORGANISM(S): Mus musculus

PROVIDER: GSE139579 | GEO | 2019/10/31

REPOSITORIES: GEO

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