Hotspot exons are common targets of splicing perturbations

ABSTRACT: RNA-seq of amiloride-treated cell culture was conducted in order to understand the characteristics that make certain exons susceptible to splicing perturbations. Amiloride is a diuretic that acts by inhibiting epithelial sodium channels in the kidney. It also behaves as a non-specific kinase inhibitor, and has been shown to affect splicing in a handful of genes, presumably by altering phosphorylation of splicing factors. Two samples were sequenced (one untreated, one treated). Differential splicing was done using rMATS version 3.2.5.

ORGANISM(S): Homo sapiens

PROVIDER: GSE140786 | GEO | 2019/11/22

REPOSITORIES: GEO