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Differential gene expression in Hep3B and Hep3B SOX4-/- cells

ABSTRACT: Overexpression of SOX4 in various kinds of cancers specimen was associated with poor prognosis of patients; however, the role of SOX4 in angiogenesis or tumor microenvironment modulation remains unclear. Therefore the endogenous SOX4 was knockout and the differential gene expression between Hep3B and Hep3B SOX4-/- cells were examined via genechip. We found that the differentially expressed genes, EzH2, a SOX4-associated partner, and CXCL12, were repressed in Hep3B SOX4-/- cells compared with parental Hep3B; these results were further assessed via qRT-PCR in Hep3B SOX4-/- versus Hep3B cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE141909 | GEO | 2020/12/01

REPOSITORIES: GEO

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Differential gene expression in Hep3B and Hep3B SOX4-/- cells

Project description:Differential gene expression in Hep3B and Hep3B SOX4-/- cells

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