Transcriptomics

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YY1 Interacts with G quadruplex DNA to Regulate Gene Expression


ABSTRACT: We systematically analyzed the alterations in mRNA transcriptome evoked by knockdown of YY1 with or without pyridostatin (PDS) treatment. Statistical analysis showed a strong correlation between PDS-regulated and YY1-regulated genes (Pearson r > 0.67), underscoring the role of YY1-G4 structure interaction in YY1-mediated gene regulation. Moreover, the RNA-Seq results revealed that YY1 can positively or negatively regulate the expression of genes through its interaction with G4 structures.

ORGANISM(S): Homo sapiens

PROVIDER: GSE142075 | GEO | 2020/08/27

REPOSITORIES: GEO

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