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Innate immune response to G-quadruplex binders in cancer cells

ABSTRACT: G-quadruplex (G4) is non-canonical nucleic acid structure involved in a plethora of fundamental biological processes. In past decades, it has been studied as a promising pharmaceutical target for anticancer therapy. However, no G4-targeting agent has shown significant clinical effects up to date. Pyridostatin (PDS), a well-known G4 binder, can induce double-stranded DNA breaks and genome instability. We have recently shown that Pyridostatin (Pyridostatin) and other G4 binders can trigger micronuclei formation in cancer cells at non-cytotoxic concentrations. As micronuclei can play a crucial role in linking genome instability to innate immunity, we have here wondered whether G4 binders can induce immune gene activation in human MCF-7 breast cancer cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE161418 | GEO | 2021/07/14

REPOSITORIES: GEO

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Differential proteomics of HeLa cells treated with PDS for 24 hours and untreated HeLa cells

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