Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: Yinzhu Hou
LAB HEAD: Fuyi Wang
PROVIDER: PXD029521 | Pride | 2022-05-19
REPOSITORIES: Pride
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20200116-Hela-1-10uMPDS-10.raw | Raw | |||
20200116-Hela-1-10uMPDS-11.raw | Raw | |||
20200116-Hela-1-10uMPDS-12.raw | Raw |
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Nucleic acids research 20220401 6
Pyridostatin (PDS) is a well-known G-quadruplex (G4) inducer and stabilizer, yet its target genes have remained unclear. Herein, applying MS proteomics strategy, we revealed PDS significantly downregulated 22 proteins but upregulated 16 proteins in HeLa cancer cells, of which the genes both contain a number of G4 potential sequences, implying that PDS regulation on gene expression is far more complicated than inducing/stabilizing G4 structures. The PDS-downregulated proteins consequently upregul ...[more]