Transcriptomics

Dataset Information

0

Mir-130a potentiates the reparative properties of human endothelial colony forming cells facing hypoxia via VEGFR2 and STAT3


ABSTRACT: Hypoxia controls reparative angiogenesis. MiRNAs are master regulators of gene expression in hypoxia and angiogenesis. However, we do not yet have a clear understanding of how hypoxia-induced miRNAs modulate vasoreparative processes. Here, we identify miR-130a as a mediator of the hypoxic response in human primary endothelial colony forming cells (ECFCs), a well-characterized subtype of endothelial progenitor. Under hypoxic conditions, miR-130a overexpression enhances ECFC pro-angiogenic capacity in vitro and potentiates their vasoreparative properties in vivo. Mechanistically, miR-130a orchestrates upregulation of VEGFR2, activation of STAT3-dependent transcription, and accumulation of HIF1α via translational inhibition of DDX6. These findings unveil a new role for miR-130a in hypoxia, whereby it modulates the VEGFR2/STAT3/HIF1α axis to increase the vasoregenerative capacity of ECFCs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE142123 | GEO | 2022/12/06

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

| PRJNA595944 | ENA
2013-11-24 | E-GEOD-51255 | biostudies-arrayexpress
2013-11-24 | GSE51255 | GEO
| PRJEB44298 | ENA
| PRJEB47233 | ENA
2022-04-22 | PXD022379 | Pride
2014-12-04 | GSE60156 | GEO
2009-02-08 | E-GEOD-13432 | biostudies-arrayexpress
2024-06-22 | PXD027331 | Pride
2020-11-24 | GSE142719 | GEO