Transcriptomics

Dataset Information

0

The miR-126/VEGFR2 axis controls the innate response to pathogen-associated nucleic acids


ABSTRACT: microRNA-126 is a microRNA predominately expressed by endothelial cells and controls angiogenesis. Unexpectedly, we found that mice deficient in miR-126 have a major impairment in their innate response to pathogen-associated nucleic acids, as well as HIV, which results in more widespread cell infection. Further examination revealed that this was due to miR-126 control of plasmacytoid DC (pDC) homeostasis and function, and that miR-126 regulates expression of TLR7, TLR9, NFkB1 and other innate response genes, as well as VEGF-receptor 2 (VEGFR2). Deletion of VEGFR2 on DCs resulted in reduced interferon production, supporting a role for VEGFR2 in miR-126 regulation of pDCs. These studies identify the miR-126/VEGFR2 axis as an important regulator of the innate response that operates through multiscale control of pDCs.

ORGANISM(S): Mus musculus

PROVIDER: GSE51255 | GEO | 2013/11/24

SECONDARY ACCESSION(S): PRJNA222226

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2013-11-24 | E-GEOD-51255 | biostudies-arrayexpress
2013-05-21 | E-MEXP-3629 | biostudies-arrayexpress
| PRJEB44298 | ENA
| PRJEB47233 | ENA
2015-07-27 | E-GEOD-51255 | ExpressionAtlas
| PRJNA222226 | ENA
2023-08-30 | GSE236141 | GEO
2023-08-30 | GSE236138 | GEO
2012-05-31 | E-GEOD-37727 | biostudies-arrayexpress
2013-10-18 | GSE32089 | GEO