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Epithelial planar bipolarity emerges from Notch- mediated asymmetric inhibition of Emx2

ABSTRACT: This dataset consists of single-cell RNA-seq (mcSCRBseq) data of neuromast hair cells from wild type and Emx2 mutant zebrafish larvae. Posterior lateral-line neuromast hair cells were isolated by fluorescence activated cell sorting (FACS) from the dissociated trunks of wild type and Emx2-mutant Tg[myo6b:actb1-EGFP] transgenic zebrafish larvae expressing the green fluorescent protein EGFP in hair cells and unipotent hair-cell progenitors (UHCPs).

ORGANISM(S): Danio rerio

PROVIDER: GSE143663 | GEO | 2020/03/05

REPOSITORIES: GEO

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Epithelial planar bipolarity emerges from Notch-mediated asymmetric inhibition of Emx2

Project description:This dataset consists of single-cell RNA-seq (10X) data of neuromast cells from zebrafish larvae. Posterior lateral-line neuromast cells were isolated by fluorescence activated cell sorting (FACS) from the dissociated trunks of Tg[myo6b:actb1-EGFP] transgenic zebrafish larvae expressing the green fluorescent protein (EGFP) in hair cells and unipotent hair-cell progenitors (UHCPs), and from Tg[Et(krt4:EGFP)sqgw57A] larvae expressing EGFP in supporting cells.

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Epithelial planar bipolarity emerges from Notch- mediated asymmetric inhibition of Emx2

Project description:Epithelial planar bipolarity emerges from Notch- mediated asymmetric inhibition of Emx2

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Expression data from Emx2 wildtype and knockout olfactory epithelium

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