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High-throughput RNAi screening for genes essential for senecent cell viability

ABSTRACT: We carried out the analysis using human skin fibroblast HCA2 (MJ90) cells. Cells were induced to be senescent cells by treatment with nutlin3a + RO3306. The cells were infected with lentiviruses enocoding shRNA against human genes (DECIPHER Human Modules 1-3). As a result, we found some gene candidates involved in senecent cell viability.

ORGANISM(S): Homo sapiens

PROVIDER: GSE145414 | GEO | 2020/02/18

REPOSITORIES: GEO

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