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Specific loss of remote fear memory by knockdown of a neuron-specific nucleosome remodeling factor BAF53b in the amygdala

ABSTRACT: Despite recent advances, molecular events and mechanisms involved in long-lasting memory formation are unclear. Here, we report a critical role for nucleosome remodeling factor BAF53b in mice. We observed an increase of BAF53b expression beyond 24 h after fear conditioning in the lateral amygdala, which was crucial for memory retention at remote time. RNA-seq analyses and behavioral rescue experiments identified fibroblast growth factor-1 (FGF1) as a candidate downstream effector.

ORGANISM(S): Mus musculus

PROVIDER: GSE145944 | GEO | 2022/02/26

REPOSITORIES: GEO

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Strain differences in responsiveness to chronic restraint stress affect remote contextual fear memory and blood transcriptomics

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