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Transcriptomic profile of ovarian tissue of third generation PCOS-like mice versus control animals

ABSTRACT: The aim of this study is to investigate ovarian transcriptomic changes by RNA-seq between 2 experimental groups, control (CNTR) and the third generation of PCOS-like mice (PAMH F3).

ORGANISM(S): Mus musculus

PROVIDER: GSE147412 | GEO | 2021/01/14

REPOSITORIES: GEO

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Methylome profile of ovarian tissue of third generation PCOS-like mice versus control animals

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Ovarian tissue of third generation PCOS-like mice versus control animals

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Ovarian tissue of third generation PCOS-like mice versus control animals

Project description:This SuperSeries is composed of the SubSeries listed below.

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Next Generation Sequencing Analysis of exosomes in follicle fluid of PCOS/non-PCOS patients

Project description:Purpose: the goals of this study are to identify the transcriptome profiling of exosome derived from follicle fluid of PCOS patients by next-generation sequencing (NGS). Methods:the transcriptome profiling of exosome derived from follicular fluid of five PCOS and five control patients were generated by deep sequencing, using Illumina GAIIx. The sequence reads that passed quality filters were analyzed at the transcript isoform level with two methods: Burrows–Wheeler Aligner (BWA) followed by ANOVA (ANOVA) and TopHat followed by Cufflinks. qRT–PCR validation was performed using TaqMan and SYBR Green assays Results: the transcriptome profiling including circRNA, lncRNA and mRNA were comparatively analyzed in the two groups of exosomes (exo-PCOS and exo-control). We focus on the circRNAs profile for further analysis. A circRNA candidate was considered to be differentially expressed if its levels between both experiment groups showed a statistically significant difference (p<0.05) of at least two-fold. Based on this criterion, we identified 16 differentially expressed circRNAs (5 up-regulated and 11 down-regulated circRNAs) between exo-PCOS and exo-control, including 3 annotated exonic circRNAs and 13 novel ones. Clustering analysis based on the differentially expressed circRNAs clustered the exo-PCOS and the exo-control groups (control). Conclusion: the circRNA expression profile of exosome derived from follicular fluid of five PCOS and five control patients were determined by RNA sequencing technology. 16 circRNAs showed significantly different expression in the exosome of PCOS FF. GO and KEGG pathway analysis indicated that the parental genes of the candidate circRNAs were involved in ovarian steroidogenesis, aldosterone synthesis and secretion, thyroid hormone signaling pathway, ubiquitin mediated proteolysis, Jak-STAT signaling pathway, and endocytosis pathway.

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DNA methylation profiling of polycystic ovarian syndrome (PCOS)

Project description:Genome-wide DNA methylation analysis on PCOS using Illumina HumanMethylation 450K BeadChips in 30 PCOS patients and 30 healthy controls Case-control design

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Long noncoding RNA expression profiles in granulosa cells from PCOS patients and women with normal ovarian reserve

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Environmental Toxicant Induced Epigenetic Transgenerational Inheritance of Ovarian Pathology and Granulosa Cell Epigenome and Transcriptome Alterations: Ancestral Origins of PCO and POI

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