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Impaired transcriptional profile in the hippocampus following loss of Kdm5a

ABSTRACT: KDM5A encodes a histone lysine demethylase that removes methyl groups from lysine 4 of histone H3, resulting in repression of target genes. In order to identify KDM5A targets, we profiled transcripts from hippocampi of WT and Kdm5a -/- mice. Loss of KDM5A resulted in dysregulation of 450 genes (FDR-corrected P ≤0.05 and log2 fold change ≥|0.3|), of which 191 genes were upregulated and 259 genes were downregulated.

ORGANISM(S): Mus musculus

PROVIDER: GSE147435 | GEO | 2020/12/14

REPOSITORIES: GEO

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