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Memory like NK cells display stem cell like properties after Zika virus infection

ABSTRACT: In this study, we show that CD27+ memory like NK cells generated following Zika virus infection exhibited stem-like features viz., self-renewal pathway, differentiation into effector cells and longer telomeres, and greater therapeutic potential than CD27- and naive CD27+ NK cells when adoptively transferred to Zika virus infected mice. In addition, epigenetic landscape of CD27+ memory like NK is markedly different compared to CD27- NK cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE148780 | GEO | 2020/12/11

REPOSITORIES: GEO

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