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Memory like NK cells display stem cell like properties after Zika virus Infection

ABSTRACT: Memory like NK cells display stem cell like properties after Zika virus Infection

PROVIDER: PRJNA623512 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11497145.fastq.gz	Fastqsanger.gz
	SRR11497146.fastq.gz	Fastqsanger.gz
	SRR11497147.fastq.gz	Fastqsanger.gz
	SRR11497148.fastq.gz	Fastqsanger.gz
	SRR11497149.fastq.gz	Fastqsanger.gz

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Memory like NK cells display stem cell like properties after Zika virus infection

Project description:In this study, we show that CD27+ memory like NK cells generated following Zika virus infection exhibited stem-like features viz., self-renewal pathway, differentiation into effector cells and longer telomeres, and greater therapeutic potential than CD27- and naive CD27+ NK cells when adoptively transferred to Zika virus infected mice. In addition, epigenetic landscape of CD27+ memory like NK is markedly different compared to CD27- NK cells.

2020-12-11 | GSE148780 | GEO

Memory like NK cells display stem cell like properties after Zika virus Infection

Project description:Here we show that Zika virus infection induces memory like NK cells that express CD27. This subset shared transcriptional changes with memory CD8 T cells, stem cells and stem like T cells. These NK cells with memory and stemness features which we term NK memory stem cells (SCMNK) demonstrated greater antiviral potential. Transcriptional data of SCMNK and non-memory NK cells is presented.

2020-12-11 | GSE148205 | GEO

Memory like NK cells display stem cell like properties after Zika virus infection

Project description:Memory like NK cells display stem cell like properties after Zika virus infection

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Memory like NK cells display stem cell like properties after Zika virus infection.

Project description:NK cells have been shown to display adaptive traits such as memory formation akin to T and B lymphocytes. Here we show that Zika virus infection induces memory like NK cells that express CD27. Strikingly, these cells exhibit stem-like features that include expansion capacity, self-renewal pathway, differentiation into effector cells, longer telomeres and gene signature associated with hematopoietic stem cell (HSC) progenitors. This subset shared transcriptional and epigenetic changes with memory CD8 T cells, stem cells and stem like T cells. These NK cells with memory and stem cell features, which we term "NK memory stem cells", demonstrated greater antiviral potential than CD27- or naïve CD27+ NK when adoptively transferred to Zika infected mice. Our results also suggest a role for the transcription factor TCF-1 in memory and stemness features of this NK subset. This study defines a unique TCF1hi CD27+ NK subset with memory capacity and stem cell features that play a role in antiviral immunity.

| S-EPMC7793296 | biostudies-literature

E-MTAB-4606

Project description:Transcription profiling by array of tumor-induced memory-like (TIML) NK cells and Cytokine-induced memory-like (CIML)-NK cells.

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Project description:we compared and reported RNA expression difference in memory and non-memory NK cell subsets

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Project description:By comparing CD94-CD56dim NK cell with or without primary stimulation treatment after 5 days, cytokine induced NK memory related molecules were identified.

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Project description:Peripheral blood NK cells were cultured into either control or cytokine-induced memory-like NK cells as described in PMID: 32614951. After differentiation, cells were labeled with hashtag antibodies and cite-seq antibodies and control and memory-like NK cells were combined and loaded onto the 10x Genomics Chromium Instrument a the McDonnell Genome Institute at Washington University School of Medicine. The following samples were analyzed to develop a classification tool for unbiased identification of memory-like NK cells in a bulk single-cell RNA-seq population.

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