Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Resident peritoneal macrophage exhibit marked sexual dimorphism in gene expression

ABSTRACT: Resident CD102+ peritoneal and plueral macrophages were FACS-sorted from unmanipulated male and female C57BL/6 mice and compared by RNAseq.

ORGANISM(S): Mus musculus

PROVIDER: GSE149014 | GEO | 2020/06/19

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

CD102- MHCII+ (F4/80lo) resident peritoneal macrophages exhibit limited sexual dimporphism in gene expression

Project description:CD102- MHCII+ (F4/80lo) peritoneal macrophages were FACS-sorted from unmanipulated male and female C57BL/6 mice and compared by RNAseq.

2022-04-14 | GSE200630 | GEO

Resident peritoneal macrophage exhibit marked sexual dimorphism in gene expression

Project description:Resident peritoneal macrophage exhibit marked sexual dimorphism in gene expression

| PRJNA627132 | ENA

CD102- MHCII+ (F4/80lo) resident peritoneal macrophages exhibit limited sexual dimporphism in gene expression

Project description:CD102- MHCII+ (F4/80lo) resident peritoneal macrophages exhibit limited sexual dimporphism in gene expression

| PRJNA825566 | ENA

Single cell RNAseq of male and female peritoneal macrophages

Project description:Determine the heterogeneity of peritoneal macrophages obtained from unmanipulated male and female C57BL/6J mice

2020-06-15 | GSE139999 | GEO

Peritoneal macrophage heterogeneity is associated with different peritoneal dialysis outcomes

Project description:Transcriptome analysis of two population of peritoneal mononuclear phagocytes (CD14+ macrophages and CD1c+ dendritic cells) in peritoneal dialysis effluent from stable (infection-free) peritoneal dialysis patients.

2017-01-23 | E-MTAB-5439 | biostudies-arrayexpress

Precision N-glycoproteomics of murine peritoneal macrophage

Project description:In this study, we profiled the precision N-glycoproteome of the murine peritoneal macrophage under different stimulation.

2021-06-12 | PXD026629 | Pride

Cultured resident and thioglycolate-elicited mouse peritoneal macrophages

Project description:In macrophage biology, resident peritoneal macrophages (RPMs) and thioglycolate-elicited peritoneal macrophages (TGPMs) have been traditionally utilized as primary cultured models. RPMs and TGPMs display distinct morphological and functional characteristics. We analyzed altered gene expression between RPMs from control mice and TGPMs from thioglycolate-injected mice.

2020-10-07 | GSE159119 | GEO

Marked sexual dimorphism in 5-HT1 receptors mediating pronociceptive effects of sumatriptan.

Project description:Amongst the side effects of triptans, a substantial percentage of patients experience injection site pain and tenderness, the underlying mechanism of which is unknown. We found that the dose range from 10fg to 1000ng (intradermal) of sumatriptan induced a complex dose-dependent mechanical hyperalgesia in male rats, with distinct peaks, at 1pg and 10ng, but no hyperalgesia at 1ng. In contrast, in females, there was 1 broad peak. The highest dose (1000ng) did not produce hyperalgesia in either sex. We evaluated the receptors mediating sumatriptan hyperalgesia (1pg, 1 and 10ng). In males, the injection of an antagonist for the serotonin (5-HT) receptor subtype 1B (5-HT1B), but not 5-HT1D, markedly inhibited sumatriptan (1pg)-induced hyperalgesia, at 10ng a 5-HT1D receptor antagonist completely eliminated hyperalgesia. In contrast, in females, the 5-HT1D, but not 5-HT1B, receptor antagonist completely blocked sumatriptan (1pg and 10ng) hyperalgesia and both 5-HT1B and 5-HT1D receptor antagonists attenuated hyperalgesia (1ng) in females, which is GPR30 estrogen receptor dependent. While selective 5-HT1D or 5-HT1B, agonists produce robust hyperalgesia in female and male rats, respectively, when co-injected the hyperalgesia induced in both sexes was attenuated. Mechanical hyperalgesia induced by sumatriptan (1pg and 10ng) is dependent on the G-protein ?i subunit and protein kinase A (PKA), in IB4-positive and negative nociceptors. Understanding the mechanisms responsible for the complex dose dependence for triptan hyperalgesia may provide useful information for the design of anti-migraine drugs with improved therapeutic profiles.

| S-EPMC5321636 | biostudies-literature

Bone marrow derived macrophage vs peritoneal macrophage

Project description:Bone marrow derived macrophage vs peritoneal macrophage

| PRJNA414129 | ENA

Expression data from wild type and Gata6-deficient tissue resident peritoneal macrophages

Project description:Tissue resident macrophages are notoriously heterogeneous, exhibiting discrete phenotypes as a consequence of tissue- and micro-anatomical niche-specific functions, but the molecular basis for this is not understood. We resolved a restricted transcriptional profile for the self-renewing population of peritoneal resident macrophages, which is expressed during homeostasis and inflammation and distinct from other MM-CM-^X. Prominent within this profile was the expression of Gata6. This study represents a characterisation of the role of Gata6 in peritoneal resident macrophage phenotype. We used microarrays to determine the patterns of gene expression in peritoneal resident MM-CM-^X in the absence of GATA-6 against wild type. Conditional 'floxed' Gata6 deficient sex-matched mice between 7 weeks old were compared against wild type

2014-05-09 | E-GEOD-47049 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data