Type I Interferon: Potential Therapeutic Target for Psoriasis?
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ABSTRACT: We observed robust overexpression of type I interferon (IFN)–inducible genes and genomic signatures that indicate T cell and dendritic cell infiltration in lesional skin. Up-regulation of mRNAs for IFN-a subtypes was observed in lesional skin compared with nonlesional skin. Enrichment of mature dendritic cells and 2 type I IFN–inducible proteins, STAT1 and ISG15, were observed in the majority of lesional skin biopsies. Concordant overexpression of IFN-c and TNF-a–inducible gene signatures occurred at the same disease sites. Keywords: Affymetrix Human Genome U133 Plus 2.0 array
ORGANISM(S): Homo sapiens
PROVIDER: GSE14905 | GEO | 2009/02/20
SECONDARY ACCESSION(S): PRJNA112007
REPOSITORIES: GEO
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