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Genome-wide mRNA profiling of PBMCs from TB patients (TB) and healthy controls (HC)

ABSTRACT: Transcriptome microarray analysis was conducted to examine the gene expression profiling of PBMCs from active TBs and HCs. All 18,853 mRNAs in the microarray were used to draw a Heatmap of differential genes according to their expression levels. The genes that exhibited significant changes in expression were used for further validation. The TB group (n=15) exhibited a significantly different profile compared to the HC (n=15) group (Fig. 1a). A total of 1,595 differentially expressed mRNAs were identified between the two groups. Of these, 335 mRNAs were up-regulated (fold change ≥ 2), and 1,260 mRNAs were down-regulated (fold change ≥ 2).

ORGANISM(S): Homo sapiens

PROVIDER: GSE149458 | GEO | 2021/11/17

REPOSITORIES: GEO

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