Genomics

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Genome wide profiling of chromatin accessibilities in murine mononuclear phagocyte lineage progenitor cells


ABSTRACT: To understand the mechanism underlying monocyte and dendritic cell development through the regulation of Irf8 expression by the 56 kb downstream (+56 kb) Irf8 enhancer, we analyzed chromatin accessibility of bone marrow cells from wild-type and Irf8-/- mice. Combined with the epigenetic profiling by H3K27 acetylation ChIP-seq, the +56 kb enhancer opens at LMPP stage, and gets activated at its highest level in mononuclear phagocyte lineage progenitor cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE149756 | GEO | 2020/12/20

REPOSITORIES: GEO

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