Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

MiRNA sequencing of RJ423EV and RJ423c141 cells

ABSTRACT: miRNA sequencing of RJ423 cells expressing an empty vector (RJ423EV) or a vector containing the miR-200c/141 cluster (RJ423c141)

ORGANISM(S): Mus musculus

PROVIDER: GSE150106 | GEO | 2021/02/08

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

miRNA sequencing of MDA-231EV, MDA-231c141 and MDA-231ba429 cells

Project description:miRNA sequencing of MDA-M-231 cells expressing an empty vector (MDA231EV), a vector containing the miR-200c/141 cluster (MDA-231c141) or a vector containing the miR-200b/200a/429 cluster (MDA-231ba429)

2021-02-08 | GSE150104 | GEO

RNA sequencing of MDA-231EV, MDA-231c141 and MDA-231ba429 cells

Project description:RNA sequencing of MDA-MB-231 cells expressing an empty vector (MDA-231EV), a vector containing the miR-200c/141 cluster (MDA-231c141) or a vector containing the miR-200b/200a/429 cluster

2021-02-08 | GSE150099 | GEO

MDA-231EV, MDA-231c141 and MDA-231ba429 cells following injection of the cells into mammary glands of NCG and subsequent mammary tumor development

2022-04-11 | GSE193479 | GEO

RNA sequencing of RJ423EV and RJ423c141 cells

Project description:RNA sequencing of RJ423 cells expressing an empty vector (RJ423EV) or a vector containing the miR-200c/141 cluster (RJ423c141)

2021-02-08 | GSE150101 | GEO

miRNA sequencing of RJ423EV and RJ423ba429 cells

Project description:miRNA sequencing of RJ423 cells expressing an empty vector (RJ423EV) or a vector containing the miR-200b/200a/429 cluster (RJ423ba429)

2021-02-08 | GSE150105 | GEO

Global changes in gene expression in response to miR-200 overexpression in 4TO7 cells

2010-12-23 | GSE19631 | GEO

TALEN-based knockout of mir-141 and mir-200c in SK-BR-3 cells

Project description:We used transcription activator-like effector nucleases (TALENs) to generate knockout cells for two related microRNAs (miRNAs), mir-141 and mir-200c, which belong to the deeply conserved mir-200 family. By carrying out deep sequencing, we identified the target genes of each miRNA. Interestingly, miR-141 and miR-200c, despite their overall similarity, suppressed largely non-overlapping groups of targets. Analysis of global mRNA level change in mir-141 and mir-200c knockout compared to wild type cells

2013-09-27 | E-GEOD-51217 | biostudies-arrayexpress

Global changes in gene expression in response to miR-200 overexpression in 4TO7 cells

Project description:Transcriptional profiling of 4TO7 cells stably overexpressing miR-200s or CDH1. We observe a dramatic shift in the gene signatures when miR-200s (cluster 2; miR-200c/141, or both clusters) are overexpressed relative to controls. However, cluster 1 overexpression (miRs-200b/a/429) alone or CDH1 overexpression does not induce global changes in gene expression to levels observed for cluster 2 (miR-200c/141) or both clusters together. One cell line (4TO7) cells: four different overexpression experiments, Cluster 1, Cluster 2, Clusters 1+2, CDH1, and respective controls, Puro vec, Hygro vec, Puro+Hygro vec and Puro vec. Each experiment has two biological replicates. Total, 16 samples.

2010-12-23 | E-GEOD-19631 | biostudies-arrayexpress

TALEN-based knockout of mir-141 and mir-200c in SK-BR-3 cells

2013-09-27 | GSE51217 | GEO

Overexpression of miR-200s in murine ovarian cancer cells (ID8 and 28-2)

Project description:Little is known about the role of miR-200s in the progression of ovarian cancer. In this study we overexpressed the miR-200c/141 cluster, the miR-200b/200a/429 cluster, or both clusters in two different murine ovarian cancer cell lines (ID8 and 28-2). As co-oeverexpression of both clusters provided the best miR-200 overexpression, we evaluated ID8 and 28-2 cells overexpressing both miR-200 clusters (ID8-200f and 28-2-200f) compared to empty vector control cells (ID8EV and 28-2EV). ID8-200f and 28-2-200f cells showed increased expression of several mesenchymal genes, decreased proliferation, decreased invasion and increased apoptosis compared to their respective controls. RNA sequencing of ID8EV, ID8-200f, 28-2EV and 28-2-200f cells revealed that overexpression of miR-200s primary regulated genes involved in epithelial mesenchymal transition EMT) and gene implicated in migration. Therefore, our work suggests that miR-200s can inhibit characteristics associated ovarian cancer progression (increased proliferation and invasion and promotion of EMT).

2024-07-03 | GSE250195 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data