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Long noncoding RNA and mRNA expression profile in brainstem of DBA/1 and C57BL/6 mouse

ABSTRACT: Our study reveals that many lncRNAs and mRNAs were differentially expressed between the brainstem of DBA/1 and C57BL/6 mouse

ORGANISM(S): Mus musculus

PROVIDER: GSE152931 | GEO | 2020/06/23

REPOSITORIES: GEO

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Dysregulated long noncoding RNAs in the brainstem of DBA/1 mouse SUDEP model

Project description:We investigated the differential expressed lncRNA and messenger RNA (mRNA) of the brainstem between primed DBA/1 mouse SUDEP model and normal DBA/1.

2020-11-01 | GSE160576 | GEO

Long noncoding RNA and mRNA expression profile in brainstem of DBA/1 and C57BL/6 mouse

Project description:Long noncoding RNA and mRNA expression profile in brainstem of DBA/1 and C57BL/6 mouse

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Dysregulated long noncoding RNAs in the brainstem of DBA/1 mouse SUDEP model

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Transcriptomic analysis in hippocampus of C57BL/6 and DBA/2 mice

Project description:Background: Previous studies have shown that significant difference in learning and memory ability existed between C57BL/6 and DBA/2 mouse. Identification of behavioral and genetic differences between these two strains is typically important for neuroscience research, indicating that they can be used to identify candidate genes for learning and memory. Objective: This study was conducted to identify candidate genes for learning and memory using C57BL/6 and DBA/2 mouse. Methods: We conducted a transcriptomic analysis in hippocampus of C57BL/6 and DBA/2 mouse using high throughput RNA deep sequencing (RNA-seq) technology to detect differentially expressed genes (DEGs). Differentially expressed genes were then functionally annotated. Results: We found a total of 31,714 genes from hippocampi of C57BL/6 and DBA/2 mice, which comprised 4,241 to 4,599 known genes with new isoforms and, 4,023 to 4,451 structurally optimized known genes. Among these genes, a total of 458 genes showed different expression in the two strains of mouse. Eight genes were randomly selected to be validated by qRT-PCR, and the expression levels of all genes were consistent with the RNA sequencing. Conclusion: Our data indicated that there were different gene expression patterns between hippocampi of C57BL/6 and DBA/2 mice. The genes associated with learning and memory discovered in the study may enhance the explanation of the behavioral differences between the two mice.

2022-08-08 | GSE210595 | GEO

Comparative analysis of gene expression in C57BL/6J and DBA/2J aging lungs.

Project description:We hypothesize that gene expression in the aging lungs of these two strains of mice are divergent thus contributing to the disparity in the phenotypes. More specifically, (1) Aging DBA/2J mice compared to aging C57BL/6 mice are known to be accelerated in their lung physiology and morphometry; (2) C57BL/6J are known to have longer natural longevity than DBA/2J mice. In order to test these hypotheses at the gene expression level, we utilized microarray analysis to examine transcriptional differences between aging lungs of both strains of mice. Keywords: comparative expression profiling

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Glomerular Transcriptome Profiling Comparing DBA/2 and C57BL/6 mice

Project description:Comparing glomerular gene expression level between mice with different susceptibilities to diabetic nephropathy, DBA/2 (susceptible) and C57BL/6 (resistant) mice, respectively. The hypothesis is that differential expression of glomerular genes regulate susceptibility to diabetic nephropathy. The results show immune related genes. Thus, glomerular inflammation may increase susceptibility to diabetic nephropathy in mice. RNA isolated from kidney glomeruli of DBA/2 and C57BL/6 mice, with or without 4 weeks diabetes induced by streptozotocin.

2016-07-22 | E-GEOD-84663 | biostudies-arrayexpress

Glomerular Transcriptome Profiling Comparing DBA/2 and C57BL/6 mice

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Dysregulated long noncoding RNAs in the brainstem of the DBA/1 mouse model of SUDEP.

Project description:BackgroundLong noncoding RNAs (lncRNAs) play an important role in many neurological diseases. This study aimed to investigate differentially expressed lncRNAs and messenger RNAs (mRNAs) in the susceptibility gaining process of primed DBA/1 mice, a sudden unexpected death in epilepsy (SUDEP) model, to illustrate the potential role of lncRNAs in SUDEP.MethodsThe Arraystar mouse lncRNA Microarray V3.0 (Arraystar, Rockville, MD) was applied to identify the aberrantly expressed lncRNAs and mRNAs between primed DBA/1 mice and normal controls. The differences were verified by qRT-PCR. We conducted gene ontology (GO), the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway and coexpression analyses to explore the possible function of the dysregulated RNAs.ResultsA total of 502 lncRNAs (126 upregulated and 376 downregulated lncRNAs) and 263 mRNAs (141 upregulated and 122 downregulated mRNAs) were dysregulated with P < 0.05 and a fold change over 1.5, among which Adora3 and Gstt4 were possibly related to SUDEP. GO analysis revealed that chaperone cofactor-dependent protein refolding and misfolded protein binding were among the top ten downregulated terms, which pointed to Hspa1a, Hspa2a and their related lncRNAs. KEGG analysis identified 28 upregulated and 10 downregulated pathways. Coexpression analysis showed fifteen dysregulated long intergenic noncoding RNAs (lincRNAs) and three aberrantly expressed antisense lncRNAs, of which AK012034 and NR_040757 are potentially related to SUDEP by regulating LMNB2 and ITPR1, respectively.ConclusionsLncRNAs and their coexpression mRNAs are dysregulated in the priming process of DBA/1 in the brainstem. Some of these mRNAs and lncRNAs may be related to SUDEP, including Adora3, Lmnb2, Hspa1a, Hspa1b, Itrp1, Gstt4 and their related lncRNAs. Further study on the mechanism of lncRNAs in SUDEP is needed.

| S-EPMC8369804 | biostudies-literature

Mus musculus strain:DBA/2J & C57BL/6J

Project description:Structural variation study of DBA/2J and C57BL/6J mice

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Distinct Transcriptional Signatures of Bone Marrow-Derived C57BL/6 and DBA/2 Dendritic Leucocytes Hosting Live Leishmania amazonensis Amastigotes

Project description:To determine the modulation of gene expression of C57BL/6 and DBA/2 BMDLs in the presence of living intracellular Leishmania amazonensis amastigotes

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