A cohesin cancer mutation reveals a role for the hinge domain in genome organization and gene expression [RNA-seq]
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ABSTRACT: Purpose: Chromatin loop formation and maintenance is regulated by the cohesin complex. Here, we investigate whether a cancer mutation to a cohesin complex subunit, SMC1A-R586W, alters genome architecture and gene expression. Method: Global gene expression was assessed using RNA-seq in wildtype and CRISPR-Cas9 genome edited SMC1A-R586W mouse embryonic stem cells (mESCs).
ORGANISM(S): Mus musculus
PROVIDER: GSE153575 | GEO | 2021/02/23
REPOSITORIES: GEO
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