Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Examination of mouse tumor infiltrating immune cell expression changes after Maoa gene knock out

ABSTRACT: Examination of mouse tumor infiltrating immune cell expression changes after Maoa gene knock out

ORGANISM(S): Mus musculus

PROVIDER: GSE153615 | GEO | 2021/02/09

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Examination of mouse tumor infiltrating immune cell expression changes after Maoa gene knock out

Project description:Examination of mouse tumor infiltrating immune cell expression changes after Maoa gene knock out

| PRJNA643488 | ENA

A synonymous mutation of rs1137070 cause the Mice Maoa gene transcription and translation to decrease

Project description:Monoamine oxidase-A (MAOA) EcoRV polymorphism (rs1137070) is a unique synonymous mutation (c.1409 T >C) of the Maoa gene that plays a role in the expression and Maoa function. This study explored the relationship between the mouse Maoa rs1137070 and the differences in Maoa gene expression. The mouse with the CC genotype of rs1137070 had a lower odds ratio of 2.44 for the Maoa level compared with the T carriers. The TT wild genotype of Maoa had elevated mRNA expression and a longer half-life, significant expression and structure differences of genotype were explored. In addition, the Maoa with different aspartic acid synonymous codons affect Maoa expression and enzyme activity that underlines the association between rs1137070 and Maoa. A dual-luciferase reporter assay confirmed that GAC was more efficient than GAT binding. On the other hand, the synonymous mutation altered the Maoa gene expression in individual mice and RNA pull-down assay suggested that it could affect the interaction with RNA binding protein. The result illustrated that synonymous mutation can indeed regulate the downregulation of gene expression, leading to changes in Maoa function and neurological-related diseases.

2024-06-10 | GSE237077 | GEO

Genome-wide analysis of MAOA on Norepinphrine induced HCC gene expression

Project description:Gene analysis of HCC cells transfected with Lenti-vector, Lenti-MAOA and stimulated with Norepinephrine Total mRNA obtained from SMMC-7721 cells transfected with Lenti-vector, Lenti-MAOA and stimulated with Norepinephrine

2013-02-10 | E-GEOD-44094 | biostudies-arrayexpress

Genome-wide analysis of MAOA on Norepinphrine induced HCC gene expression

Project description:Gene analysis of HCC cells transfected with Lenti-vector, Lenti-MAOA and stimulated with Norepinephrine

2013-02-10 | GSE44094 | GEO

Elevated MAOA Expression Enhances Tumor Growth In-vivo and Alters Transcriptional Profiles

Project description:Subcutaneous xenografts were derived utilizing either PC3 cells engineered to stably overexpress MAOA or empty vector controls in mice receiving docetaxel treatment. Tumor gene expression was profiled using Agilent gene expression microarrays. Custom Agilent 44K whole human genome expression oligonucleotide microarrays were used to profile subcutaneous xenograft tumors derived utilizing either PC3 cells engineered to stably overexpress MAOA or empty vector controls in mice receiving docetaxel treatment. Total RNA was isolated and amplified prior to hybridization against a common reference pool of prostate tumor cell lines.

2014-07-03 | E-GEOD-53944 | biostudies-arrayexpress

Elevated MAOA Expression Enhances Tumor Growth In-vivo and Alters Transcriptional Profiles

2014-07-03 | GSE53944 | GEO

anaerobic knock-out

Project description:Six different knock-out strains' expression data under anaerobic condition Keywords: parallel sample

2004-03-10 | GSE1107 | GEO

aerobic knock-out

Project description:Six different knock-out strains' expression data under aerobic condition Keywords: parallel sample

2004-03-10 | GSE1106 | GEO

Microarray of wild type, Shp2 knock-out, Pten knock-out and double knock-out erythroblasts

Project description:the gene expression profiling results provide important information for the genes regulated by crosstalk between Shp2 and Pten mediated signal pathways Total RNA was extracted from CD71mid Ter119high erythroblasts isolated from the bone marrow of wide type, Shp2 knock-out, Pten knock-out and double knock-out mice

2013-07-03 | E-GEOD-48477 | biostudies-arrayexpress

Transcriptional analysis of the effect of monoamine oxidase A (MAOA) in human prostate cancer enzalutamide (ENZ)-resistant C4-2B (C4-2B ENZR) and LNCaP cells

Project description:The overall goal of this study was to compare gene expression profiles in control and MAOA-knockdown prostate cancer cells.

2020-11-19 | GSE161691 | GEO