Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Time-course analysis of intestinal postnatal response to IUGR at 0-2 and 5 days

ABSTRACT: Kinetic comparative study of distal small intestine and colon of IntraUterine Growth Restricted vs. normal birth weight piglets at the age of 0, 2 and 5 days of life. Keywords: Nutritional state and time-course comparative analysis.

ORGANISM(S): Sus scrofa

PROVIDER: GSE15384 | GEO | 2010/01/01

SECONDARY ACCESSION(S): PRJNA117119

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Time-course analysis of intestinal postnatal response to IUGR at 0-2 and 5 days

Project description:Kinetic comparative study of distal small intestine and colon of IntraUterine Growth Restricted vs. normal birth weight piglets at the age of 0, 2 and 5 days of life. Keywords: Nutritional state and time-course comparative analysis. 66 samples - One sample versus a pool

2010-06-24 | E-GEOD-15384 | biostudies-arrayexpress

Postnatal response of the intestine in 19 d-old IUGR piglets

Project description:Comparison of distal small intestine and colon in IntraUterine Growth Restricted versus normal birth weight piglets at the age of 19 days of life. Keywords: Nutritional state comparative analysis.

2010-01-01 | GSE14716 | GEO

Postnatal response of the intestine in 19 d-old IUGR piglets

2010-05-16 | E-GEOD-14716 | biostudies-arrayexpress

Postnatal intestinal response of IUGR piglets to high proteins before weaning

Project description:Comparison of distal small intestine in IntraUterine Growth Restricted piglets fed either adequate or high protein artificial milks during suckling period. Comparison at 7 and 28 days of life. Keywords: Nutritional response

2010-01-01 | GSE18249 | GEO

Postnatal intestinal response of IUGR piglets to high proteins before weaning

2010-05-16 | E-GEOD-18249 | biostudies-arrayexpress

RNA-sequencing data of liver tissue of intrauterine growth restricted (IUGR) piglets with or without supplementary energy treatment

Project description:RNA-sequencing data of liver tissue of intrauterine growth restricted (IUGR) piglets with or without supplementary energy treatment

2023-03-01 | GSE226052 | GEO

Postnatal leptin promotes organ maturation and development in IUGR piglets.

Project description:Babies with intra-uterine growth restriction (IUGR) are at increased risk for experiencing negative neonatal outcomes due to their general developmental delay. The present study aimed to investigate the effects of a short postnatal leptin supply on the growth, structure, and functionality of several organs at weaning. IUGR piglets were injected from day 0 to day 5 with either 0.5 mg/kg/d leptin (IUGRLep) or saline (IUGRSal) and euthanized at day 21. Their organs were collected, weighed, and sampled for histological, biochemical, and immunohistochemical analyses. Leptin induced an increase in body weight and the relative weights of the liver, spleen, pancreas, kidneys, and small intestine without any changes in triglycerides, glucose and cholesterol levels. Notable structural and functional changes occurred in the ovaries, pancreas, and secondary lymphoid organs. The ovaries of IUGRLep piglets contained less oogonia but more oocytes enclosed in primordial and growing follicles than the ovaries of IUGRSal piglets, and FOXO3A staining grade was higher in the germ cells of IUGRLep piglets. Within the exocrine parenchyma of the pancreas, IUGRLep piglets presented a high rate of apoptotic cells associated with a higher trypsin activity. In the spleen and the Peyer's patches, B lymphocyte follicles were much larger in IUGRLep piglets than in IUGRSal piglets. Moreover, IUGRLep piglets showed numerous CD79(+) cells in well-differentiated follicle structures, suggesting a more mature immune system. This study highlights a new role for leptin in general developmental processes and may provide new insight into IUGR pathology.

| S-EPMC3669417 | biostudies-literature

Maternal hyperglycemia induces alterations in hepatic amino acid, glucose and lipid metabolism of neonatal offspring: Multi-omics insights from a diabetic pig model

Project description:Intrauterine exposure to disturbed maternal glucose metabolism is associated with adverse consequences for the offspring. Hepatic disorders in affected offspring emerge in early development; thus, detection of disease biomarkers at an early stage may elucidate the underlying mechanisms of maternal hyperglycemia-induced metabolic disease and improve timely diagnosis and treatment strategies. To systematically study the molecular consequences of maternal hyperglycemia, we used data independent acquisition (DIA) proteomics and compared the molecular profiles of liver of three days old wild-type piglets born to a transgenic hyperglycemic pig model with those of wild-type piglets born to normoglycemic mothers.

2023-07-10 | PXD040305 | Pride

Transcriptome in rat kidneys exposed to a fetal low-protein diet on postnatal days 5, 10, and 28

Project description:Early in fetal development, maternal nutritional environments are expected to induce changes in epigenetic regulation in offspring.In the present study, we integrated methylome and transcriptome data to identify potential salt-sensitive hypertension genes using the kidneys of pups exposed to a low-protein diet throughout their fetal life. We aimed to uncover how specific candidate marker genes are modified over time and under different nutritional interventions at an early age. Using the kidneys of pups exposed to a low-protein diet (LP) compared to those exposed to a control diet (CN) during fetal life, we searched for candidate genes by integrating data from both methylome and transcriptome profiling.Transcriptome analyses were used to identify genes with differential expression.

2023-10-04 | GSE215329 | GEO

Rat IUGR islet transcriptome sequencing at 2 time points

Project description:Intrauterine growth restriction (IUGR) increases the risk of developing type 2 diabetes during adulthood. At day 18 of gestation, we used bilatual uterine artery ligation (BUAL) to restrict nutrient supply to developing rat fetuses to produce IUGR pups. At 2 and 10 weeks of age pancreatic islets were isolated and total RNA extracted using Trizol. Samples with RNA integrity numbers greater than 7 were used to generate libraries

2018-09-11 | GSE104017 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data