Proteomics

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Maternal hyperglycemia induces alterations in hepatic amino acid, glucose and lipid metabolism of neonatal offspring: Multi-omics insights from a diabetic pig model

ABSTRACT: Intrauterine exposure to disturbed maternal glucose metabolism is associated with adverse consequences for the offspring. Hepatic disorders in affected offspring emerge in early development; thus, detection of disease biomarkers at an early stage may elucidate the underlying mechanisms of maternal hyperglycemia-induced metabolic disease and improve timely diagnosis and treatment strategies. To systematically study the molecular consequences of maternal hyperglycemia, we used data independent acquisition (DIA) proteomics and compared the molecular profiles of liver of three days old wild-type piglets born to a transgenic hyperglycemic pig model with those of wild-type piglets born to normoglycemic mothers.

INSTRUMENT(S): Q Exactive HF-X

ORGANISM(S): Sus Scrofa Domesticus (domestic Pig)

TISSUE(S): Liver

DISEASE(S): Diabetes Mellitus

SUBMITTER: Bachuki Shashikadze  

LAB HEAD: Thomas Fröhlich

PROVIDER: PXD040305 | Pride | 2023-07-10

REPOSITORIES: pride

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Action DRS
D13_m_d3_PNG.raw Raw
D14_f_d3_PNG.raw Raw
D18_f_d3_PNG.raw Raw
D19_f_d3_PNG.raw Raw
D1_f_d3_PHG.raw Raw
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Maternal hyperglycemia induces alterations in hepatic amino acid, glucose and lipid metabolism of neonatal offspring: Multi-omics insights from a diabetic pig model.

Shashikadze Bachuki B   Valla Libera L   Lombardo Salvo Danilo SD   Prehn Cornelia C   Haid Mark M   Riols Fabien F   Stöckl Jan Bernd JB   Elkhateib Radwa R   Renner Simone S   Rathkolb Birgit B   Menche Jörg J   Hrabĕ de Angelis Martin M   Wolf Eckhard E   Kemter Elisabeth E   Fröhlich Thomas T  

Molecular metabolism 20230704

<h4>Objective</h4>To gain mechanistic insights into adverse effects of maternal hyperglycemia on the liver of neonates, we performed a multi-omics analysis of liver tissue from piglets developed in genetically diabetic (mutant INS gene induced diabetes of youth; MIDY) or wild-type (WT) pigs.<h4>Methods</h4>Proteome, metabolome and lipidome profiles of liver and clinical parameters of serum samples from 3-day-old WT piglets (n = 9) born to MIDY mothers (PHG) were compared with those of WT piglets  ...[more]

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