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DUX4 induces a homogeneous sequence of molecular changes, culminating in cellular apoptosis

ABSTRACT: Single cell RNA sequencing was performed on a CML derived cell line, which contains a TET-ON inducible system for DUX4 inducible expression (DIE). In attempt of finding key players early in the DUX4 induced process, we performed single-cell RNA sequencing (SCS) on induced DIE cells, as early as 2 hours after induction. In a sequential manner, DIE cells induced for 3, 4, and 6 hours were also collected and used for SCS. By analysing these cells at a single cell level, we aimed to find (subtle) changes in the DIE cell transcriptome, that start early after DUX4 induction.

ORGANISM(S): Homo sapiens

PROVIDER: GSE156154 | GEO | 2021/01/01

REPOSITORIES: GEO

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