Dataset Information
GLI1 knock-down in Panc1 cells
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Michael Krause
PROVIDER: E-MEXP-3379 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
GLI1 inhibition promotes epithelial-to-mesenchymal transition in pancreatic cancer cells.
Cancer research 20111115 1
The Hedgehog (HH) pathway has been identified as an important deregulated signal transduction pathway in pancreatic ductal adenocarcinoma (PDAC), a cancer type characterized by a highly metastatic phenotype. In PDAC, the canonical HH pathway activity is restricted to the stromal compartment while HH signaling in the tumor cells is reduced as a consequence of constitutive KRAS activation. Here, we report that in the tumor compartment of PDAC the HH pathway effector transcription factor GLI1 regul ...[more]
