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High resolution chromosome conformation capture from gene promoters at COVID-19, T1D, AS and RBC GWAS loci

ABSTRACT: Genome Wides Association Studies (GWAS) have identified tens of thousands of associations between human genetic variation and common disease. The majority of causative variants lie in regulatory elements that are located some distance from their target genes. High resolution chromosome conformation capture (3C) has proven useful for identifying enhancer-promoter interaction. We employed targeted Capture-C at loci with GWAS for severe COVID-19, Type-1 Diabetes (T1D), Ankylosing spondylitis (AS) and red blood cell traits (RBC)

ORGANISM(S): Homo sapiens

PROVIDER: GSE159867 | GEO | 2021/08/13

REPOSITORIES: GEO

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