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Serca2b inhibition aids T cell activation and selectively promotes tumor cell death

ABSTRACT: We found that T cells and tumor cells are differentially dependent on Atp2a2 for their survival. In fact, Atp2a2 KO T cells have increased function, whereas Atp2a2 KO tumor cells die. Thapsigargin is a drug that targets the protein product of Atp2a2: Serca2b. We found that in tumor cells, the SAGA complex transmits TG signals to induce tumor cell death, principally via Ccdc101.

ORGANISM(S): Mus musculus

PROVIDER: GSE161209 | GEO | 2023/11/10

REPOSITORIES: GEO

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SAGA and ATAC histone acetyl transferase complexes regulate distinct sets of genes and ATAC defines a class of p300-independent enhancers

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