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Clinical optimization and molecular characterization of an engineered Type-1 regulatory T cell therapy

ABSTRACT: purpose: To investigate transcriptional changes in engineered Tr1 Cells Methods: RNA sequencing of polyA enriched donor matched CD4 T cells lentiviral transduced with human IL-10 (CD4IL-10) or control GFP (CD4GFP) Results: 142 total DEGs were identified as differentially expressed between CD4IL-10 and CD4GFP. GEO analysis found highest enrichment in genes related to cytokine signaling and cytotoxicity. Conclusion: Engineered Tr1 cells upregulate primarily cytotoxicity related effector molecules related to the myeloid cell killing phenotype observed in Tr1 cells

ORGANISM(S): Homo sapiens

PROVIDER: GSE162915 | GEO | 2021/12/08

REPOSITORIES: GEO

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Tolerogenic Dendritic Cells Engineered with IL-10 and Antigen Control Pathogenic T Cell Responses and Promote Type 1 T Regulatory Cells

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