Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mesenchymal Stem Cells (MSCs) Alleviate Experimental Immune-mediated Liver Injury via Chitinase 3-like protein 1-mediated T cell suppression

ABSTRACT: RNA-seq for MSCs from human bone marrow (BM-MSCs), olfactory mucosa (OM-MSCs), and umbilical cord (UC-MSCs) (2 donors for each). RNA-sequencing for human naïve CD3+ T cells, CD3+ T cells activated with PHA (2.5 μg/mL) for 48 h， and CD3+ T cells co-cultured with human UC-MSCs in the presence of PHA for 48 h.

ORGANISM(S): Homo sapiens

PROVIDER: GSE166327 | GEO | 2021/02/09

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Shared Molecules

Only show the datasets with similarity scores above: 0.5

Threshold

0.5

Similar Datasets

Inflammation-inducible promoters to overexpress immune inhibitory factors by MSCs

Project description:Umbilical cord mesenchymal stromal cells (UC-MSCs) were treated with different concentration with hIL10 and the influences on the secretome analyzed

2023-08-31 | GSE224735 | GEO

Mesenchymal Stem Cells (MSCs): Control vs. PTH-stimulated

Project description:Transcriptional profiling of human MSCs comparing control MSCs with parathyroid hormone (PTH)-stimulated MSCs. PTH-stimulated MSCs were treated with 0.1 nM recombinant human PTH (N-terminal fragment, amino acids 1-34) for 48 hours. Human MSCs were isolated from a bone marrow sample obtained from a healthy adult volunteer.

2014-02-01 | GSE43148 | GEO

Single Cell Transcriptomic Analysis of Clinical-used MSCs Derived From Adipose Tissue, Bone Marrow, Placenta Membrane and Umbilical Cord

Project description:Here, we use single cell transcriptomics to characterize a dynamic senescence process of in vitro expanded MSC products from adipose tissue (AD), bone marrow (BM), placenta membrane (PM) and umbilical cord (UC). We found that cultured MSCs underwent progressive cell aging. As compared to perinatal MSCs (derived from PM and UC), adult MSCs (derived from AD and BM) showed higher degree of senescence and impaired immunosuppressive function. Moreover, we identified the transcriptional network regulating the intra-population functional diversity, which provides us guidance to drive reprogramming of determined MSCs lineage with specific cellular functions for a particular therapeutic intent.

2023-06-19 | GSE200161 | GEO

Mesenchymal Stem Cells (MSCs): Control vs. PTH-stimulated

2014-02-01 | E-GEOD-43148 | biostudies-arrayexpress

Identification of the MSCs secretome

Project description:the secretomeS of MSCs co-culturing with/without U937 cells after 48 h

2020-01-05 | PXD016939 |

Mesenchymal Stem Cells (MSCs) Alleviate Experimental Immune-mediated Liver Injury via Chitinase 3-like protein 1-mediated T cell suppression

Project description:Mesenchymal Stem Cells (MSCs) Alleviate Experimental Immune-mediated Liver Injury via Chitinase 3-like protein 1-mediated T cell suppression

| PRJNA700504 | ENA

Expression data from human fetal cardiac MSCs

Project description:The instrinsic regenerative capacity of human fetal cardiac mesenchymal stromal cells (MSCs) has not been fully characterised. Here we demonstrate that we can expand cells with characteristics of cardiovascular progenitor cells from the MSC population of human fetal hearts with only minor fluctuations over time in culture (from day 15 to day 48). We used microarray to compare the gene-expression profile of cultured human fetal cardiac MSCs over time (from day 15 to day 48). MSCs from human fetal hearts were cultured on GelTrex in a defined medium stimulating the canonical Wnt/beta-catenin pathway. Samples from three different time points (day 15, 27 and 48) were compared on microarray.

2016-02-19 | E-GEOD-78047 | biostudies-arrayexpress

Expression data from human fetal cardiac MSCs

2016-02-19 | GSE78047 | GEO

Comparison of the Transcriptome Profile of four Tissue Specific MSCs: Significance and Therapeutic Implications

Project description:Performing global gene expression profiling for different types of (Mesenchymal stem cells) MSCs can provide important information that might help in understanding the biology and ontogeny of MSCs. Additionally, it might help in the understanding of the propensity and capacity of MSCs from a particular source to differentiate toward a particular lineage or adopt a certain fate. We used microarrays to detail the global gene expression profiling for different types of MSCs including bone marrow (BM), Adipose Tissue (AT), Umbilical cord (UC) and placenta(PL). The MSCs transcriptome profile was additionally compared to the transcriptome profile of dermal fibroblasts.

2018-06-15 | GSE108511 | GEO

RNA sequence of ISL1-MSCs and Ctrl-MSCs

Project description:RNA sequence of ISL1-MSCs and Ctrl-MSCs

| PRJNA421939 | ENA