Transcriptomics

Dataset Information

0

Single Cell Transcriptomic Analysis of Clinical-used MSCs Derived From Adipose Tissue, Bone Marrow, Placenta Membrane and Umbilical Cord


ABSTRACT: Here, we use single cell transcriptomics to characterize a dynamic senescence process of in vitro expanded MSC products from adipose tissue (AD), bone marrow (BM), placenta membrane (PM) and umbilical cord (UC). We found that cultured MSCs underwent progressive cell aging. As compared to perinatal MSCs (derived from PM and UC), adult MSCs (derived from AD and BM) showed higher degree of senescence and impaired immunosuppressive function. Moreover, we identified the transcriptional network regulating the intra-population functional diversity, which provides us guidance to drive reprogramming of determined MSCs lineage with specific cellular functions for a particular therapeutic intent.

ORGANISM(S): Homo sapiens

PROVIDER: GSE200161 | GEO | 2023/06/19

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2021-02-09 | GSE166327 | GEO
2019-09-11 | GSE137173 | GEO
2019-11-19 | GSE136397 | GEO
2018-06-15 | GSE108511 | GEO
2011-02-19 | E-GEOD-20463 | biostudies-arrayexpress
2019-05-15 | GSE117837 | GEO
2024-04-30 | GSE262787 | GEO
2021-06-02 | GSE167219 | GEO
2022-10-03 | GSE199826 | GEO
2021-08-30 | PXD018655 | Pride