Transcriptomics

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LSD1 functions through CoREST to maternally reprogram histone methylation


ABSTRACT: Since the germline mortality phenotype of met-2; spr-1 mutants lie between spr-5; met-2 mutants and single mutants, it raises the possibility that maternal SPR-5 reprogramming may be partially dependent upon the SPR-5 interacting partner SPR-1. If mutating spr-1 partially compromises SPR-5 maternal reprogramming, we would expect that the gene expression changes in met-2; spr-1 mutants would be similar to spr-5; met-2 mutants, but that the changes would be less severe in met-2; spr-1 mutants. To test this possibility, we performed RNA-seq on spr-1, met-2, and met-2; spr-1 mutant L1 progeny compared to N2 L1 progeny.

ORGANISM(S): Caenorhabditis elegans

PROVIDER: GSE168081 | GEO | 2021/03/03

REPOSITORIES: GEO

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