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RNA-seq of Human Epithelioid Hemangioendothelioma and genetically engineered mouse model of EHE

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE168495 | GEO | 2021/03/25

REPOSITORIES: GEO

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RNA-Seq of genetically engineered mouse model of Epithelioid Hemangioendothelioma tumors

Project description:Epithelioid hemangioendothelioma (EHE) is a rare vascular sarcoma that is associated with a WWTR1-CAMTA1 fusion gene in greater than 90% of cases. Using an adaptation of the FLEx system, we generated a genetically engineered mouse model of EHE whereby the endogenous Wwtr1 Locus is replaced with an Wwtr1-Camta1 locus. RNA was isolated from the resultant tumors and from control liver tissue and RNA sequencing was performed. Cross species analysis between human and mice tumors demonstrated murine EHE maintains the defining transcriptional features of human EHE.

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scRNA-Seq of genetically engineered mouse model of Epithelioid Hemangioendothelioma tumors

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scRNA-Seq of genetically engineered mouse model of Epithelioid Hemangioendothelioma tumors

Project description:scRNA-Seq of genetically engineered mouse model of Epithelioid Hemangioendothelioma tumors

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RNA-Seq of genetically engineered mouse model of Epithelioid Hemangioendothelioma tumors

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Inducible Astrocytomas in Genetically Engineered Mice

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RNA-seq of Human Epithelioid Hemangioendothelioma and genetically engineered mouse model of EHE

Project description:RNA-seq of Human Epithelioid Hemangioendothelioma and genetically engineered mouse model of EHE

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Epithelioid hemangioendothelioma: a case report.

Project description:Epithelioid hemangioendothelioma (EHE) is a rare vascular tumor with limited clinical data that can guide treatment choices. The diagnosis of EHE is based on its unique histological, immunohistochemical, and molecular characteristics. Differential diagnoses are broad and include autoimmune diseases. Treatments include hepatic resection, liver transplantation, systemic/regional chemotherapy, and radiotherapy. We describe EHE in a patient with weight loss and general weakness. The prognosis of EHE is variable, with few cases demonstrating an indolent clinical course, whereas others tend to metastasize. In our case, hepatic EHE had metastasized to the lungs and brain. Histopathological examination of the liver tissue revealed an epithelial hemangioendothelioma. On CK7 staining, hepatocytes were clearly reactive and arranged in the plates (CK7: negative), with positive immunohistochemical staining for CD34 (CD34: positive) alone. Surveillance was conducted and the clinical course was better than expected, probably due to her relatively good general condition, the lack of genetic factors associated with her familial medical history, and normal levels of tumor markers such as α-fetoprotein and carcinoembryonic antigen (CEA). During a follow-up examination, she was asymptomatic with a healthy general appearance. The prognosis of EHE is variable, with few cases demonstrating an indolent clinical course, whereas others tend to metastasize. The treatment method for EHE should be determined according to the patient's condition.

| S-EPMC11292091 | biostudies-literature

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