Bioengineered embryoids mimic post-implantation development in vitro [Embryoids10XG]
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ABSTRACT: Here, we report a bioengineering-inspired approach to simultaneously coax mouse embryonic stem cells (ESCs) into hundreds of uniform epiblast-like (EPI) aggregates in a solid matrix-free manner. When co-cultured with mouse trophoblast stem cell (TSC) aggregates, the resulting hybrid structures initiate gastrulation-like events and undergo axial morphogenesis to yield structures, termed EpiTS embryoids, with a pronounced anterior development, including brain-like regions.
ORGANISM(S): Mus musculus
PROVIDER: GSE171209 | GEO | 2021/04/12
REPOSITORIES: GEO
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