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UVB-induced skin autoinflammation due to NLRP1 mutation and its inhibition by anti-IL-1b antibody

ABSTRACT: To analyze the pathogenic mechanism of the autoinflammatory skin syndromes caused by an NLRP1 mutation, we sought to generate Nlrp1b mutation knock-in mice mice as a mouse model of cutaneous autoinflammatory lesions due to NLRP1 mutants, and examine the expression of proteins, such as cytokines, and the mRNA expression profile, including inflammasome-related genes in the model lesions.

ORGANISM(S): Mus musculus

PROVIDER: GSE172065 | GEO | 2022/06/14

REPOSITORIES: GEO

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UVB-induced skin autoinflammation due to NLRP1 mutation and its inhibition by anti-IL-1b antibody

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