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UVB-induced skin autoinflammation due to NLRP1 mutation and its inhibition by anti-IL-1b antibody

ABSTRACT: UVB-induced skin autoinflammation due to NLRP1 mutation and its inhibition by anti-IL-1b antibody

PROVIDER: PRJNA721946 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR14238172_1.fastq.gz	Fastqsanger.gz
	SRR14238172_2.fastq.gz	Fastqsanger.gz
	SRR14238173_1.fastq.gz	Fastqsanger.gz
	SRR14238173_2.fastq.gz	Fastqsanger.gz
	SRR14238174_1.fastq.gz	Fastqsanger.gz

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UVB-induced skin autoinflammation due to NLRP1 mutation and its inhibition by anti-IL-1b antibody

Project description:To analyze the pathogenic mechanism of the autoinflammatory skin syndromes caused by an NLRP1 mutation, we sought to generate Nlrp1b mutation knock-in mice mice as a mouse model of cutaneous autoinflammatory lesions due to NLRP1 mutants, and examine the expression of proteins, such as cytokines, and the mRNA expression profile, including inflammasome-related genes in the model lesions.

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Oxidized thioredoxin-1 restrains the NLRP1 inflammasome

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