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The effect of microglial STAT3 signaling on early postnatal brain development

ABSTRACT: Microglia play critical roles in the maturation and refinement of neural networks of the developing brain. The goal of this study was to investigate the role of microglial STAT3 in postnatal brain development. This experiment was aimed to determine gene profiles (RNA-seq) of wild-type and Stat3 mutant microglia. Cx3cr1CreERT2/+:Stat3loxP mice were generated to achieve tamoxifen-inducible deletion of exon 22 of the Stat3 gene in microglia. mRNA was prepared from acutely isolated microglia from postnatal day 8 (P8) pups that received tamoxifen from postnatal day 1 to 3. Overall, we found that Stat3 mutant produced signficantly higher levels of inlfammatory cytokines and had compromised DNA damage checkpoints.

ORGANISM(S): Mus musculus

PROVIDER: GSE173110 | GEO | 2024/12/31

REPOSITORIES: GEO

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